Detroit, MI (Sports Network) - Ramon Santiago homered twice, and the Detroit Tigers prevented the Rays from clinching the first division title in franchise history with a 7-5 win over Tampa Bay in the opener of a four-game series.

Ben Zobrist homered twice and drove in four for the Rays, who could have clinched the AL East with a win. Instead Tampa Bay will have to wait at least another day to celebrate.

A Boston Red Sox loss to the Cleveland Indians on Thursday night would have handed the division title to the Rays, who have already locked up the first playoff spot in franchise history, The Red Sox, though, beat the Indians, 6-1.

Mike Hessman, Dusty Ryan, and Curtis Granderson each hit solo homers for the Tigers, who hit five solo shots -- four off of Rays left-hander Scott Kazmir. Armando Galarraga (13-6) got the win despite allowing five runs on six hits in 7 2/3 innings, with five strikeouts and two walks for the Tigers, who had dropped six straight.

"It was good to shake hands after the game, we haven't been able to do that for a while," said Tigers manager Jim Leyland.

Kazmir (12-8) gave up four runs -- all on leadoff homers -- on six hits in five innings, with eight strikeouts and two walks for the Rays, who had won four straight.

"I kept getting into a groove and then getting out of it," said Kazmir. "I could never really get into a comfort zone. On a lot of the pitches they hit out, I didn't feel like I threw them with much conviction."

Zobrist's second long ball of the day, a three-run shot to dead center field with two outs in the eighth, pulled Tampa Bay within two runs, and ended Galarraga's day. Tigers reliever Fernando Rodney came on and recorded the last four outs, however, for his 11th save.

Zobrist belted a one-out solo homer in the first to give the Rays the early lead, but with the ball flying out of Comerica Park as much as it did Thursday, the one-run lead didn't hold long. Santiago went deep to left to lead off the home half, knotting the game at 1-1.

Santiago took Kazmir out to left again to lead off the third, for just his third homer of the season and ninth of his career. Hessman's leadoff homer in the fourth added another run, and Ryan's leadoff homer in the fifth, his second of the year, gave the Tigers a 4-1 lead.

Evan Longoria's solo blast to left with one out in the seventh cut Tampa's deficit to two runs, but the Tigers answered with three in the home half.

Santiago led off with a single and came home on Marcus Thames' double to left. Thames eventually came home on a Miguel Cabrera sacrifice fly, and Granderson followed with a solo homer down the line in right, his 21st, for a 7-2 Detroit lead.