Cincinnati, OH (Sports Network) - Ken Griffey Jr. blasted a game-winning two- run shot in the ninth inning for his 603rd career homer, giving the Cincinnati Reds a dramatic come-from-behind 4-3 win over the Pittsburgh Pirates in the opener of a three-game series at Great American Ball Park.

Jerry Hairston Jr. homered and doubled in four at-bats while Brandon Phillips had two singles and a run scored for Cincinnati, which has won three straight. Francisco Cordero (3-1) was credited with the win after escaping a bases- loaded jam in the ninth.

Adam LaRoche was 3-for-3 with a two-run homer and a sac fly, accounting for all three Pittsburgh runs, as the Pirates dropped their second straight and fourth in their last five games.

Matt Capps (1-3) came on in the ninth, allowing a leadoff double to David Ross before Griffey connected on his 10th of the season, a line-shot to right- center, sending the Cincinnati crowd into a frenzy.

Cincy's Aaron Harang held his own through seven frames, surrendering three runs on seven hits and a walk while fanning eight in the no-decision.

The Bucs' Paul Maholm pitched well over seven innings, allowing two runs on five hits and two walks while recording five strikeouts. The lefty remained unbeaten in his last seven starts without a decision.

Pittsburgh notched the game's first run in the second. Ryan Doumit led off with a double to right-center, moved to third on a groundout and scored on a sacrifice fly from LaRoche.

Cincy tied it up in the third with a leadoff homer from Hairston, who turned on a Maholm fastball, driving it into the seats in left.

LaRoche gave Pittsburgh the lead back in the sixth with a two-run homer over the wall in right-center. Xavier Nady doubled before LaRoche's at-bat.

The Reds cut the lead to one in the bottom half of the sixth. Maholm loaded the bases on a single, hit batsmen and a walk before Jay Bruce plated a run with a fielder's choice groundout.

Pittsburgh loaded the bases in the ninth off Cordero with two walks and a hit batsmen, but failed to get a run across as Doumit grounded out to end the frame.