Boston, MA (Sports Network) - Tim Wakefield allowed two hits and no runs over seven innings, and Kevin Cash hit a key three-run homer as Boston topped Arizona, 5-0, in the finale of a three-game interleague set from Fenway Park.

Wakefield (5-5) fanned six with only one walk, tying his season low for hits allowed which was first set in an eight-inning 5-0 victory at Detroit on May 6.

Cash slugged his first homer of the season for the Red Sox, who took two of three in the series and have won three of four overall. Brandon Moss knocked in a pair of runs while Mike Lowell added two hits and scored three times.

Kevin Youkilis returned to the lineup at first base after missing Tuesday's game with an eye injury suffered during Monday's game. He collected a single in four at-bats.

Orlando Hudson finished 2-for-4 for the Diamondbacks, who have dropped five of six. Randy Johnson (4-6) was charged with eight hits and two runs over six innings en route to losing his fifth consecutive start.

Facing Juan Cruz in the eighth and nursing a two-run lead, the Red Sox picked up valuable insurance. Lowell walked and Coco Crisp doubled to center, setting the stage for Cash who crushed a fastball over the Green Monster and out of the park for a 5-0 lead.

"A great at-bat off Cruz," said Sox manager Terry Francona of Cash. "He was getting to his fastball, pulled a couple foul but was on them. Then he gets a slider and hits it out of the ball park. It's a lot better to play 5-0 than 2-0, especially the way the ninth inning unfolded."

Craig Hansen did not survive a bases-loaded jam in the ninth. Jonathan Papelbon was called on to strike out Chad Tracy to end the contest and earn his 23rd save.

The Sox put up a run in the second. Lowell singled to start the frame followed by Crisp's double off the wall in center. Cash's fly to center could not advance runners but Moss' grounder to first plated Lowell.

Wakefield confounded Diamondbacks batters early, yielding just one hit and recording six strikeouts through the first five innings. He did not allow a runner past first base in that stretch, and Chris Young -- who walked with two outs in the fifth -- was thrown out trying to steal second to end the frame.

In the home half, Julio Lugo doubled and Dustin Pedroia added a one-out infield single to put runners at the corners, but Youkilis grounded into an inning-ending double play.

Boston loaded the bases with one out in the sixth and only managed a sacrifice fly run from Moss which put them ahead by two.

In the seventh, Hudson's one-out double off the Monster nearly cleared the wall for a homer, but Wakefield completed his outing by setting down the next two batters.

"You try to battle. You try to see enough of it," said D-Backs manager Bob Melvin of the troubles his club faced against a knuckelballer. "We had Tom Candiotti, one of our announcers, throw a little early BP to us today to try to simulate a little bit of what we had to deal with tonight. It seemed like he had a good knuckler tonight and kept us off balance."