Pittsburgh, PA (Sports Network) - Ryan Doumit and Jose Bautista both homered as Pittsburgh routed the New York Yankees, 12-5, in the opener of a three-game interleague set at PNC Park.

The Yankees were returning to Pittsburgh for the first time since one of the most crushing defeats in their storied history. The Pirates beat them in the seventh game of the 1960 World Series on a bottom of the ninth inning home run by Hall of Famer Bill Mazeroski.

To this day, Mazeroski's homer remains the only Game 7-ending homer in World Series history.

Doumit finished 3-for-5 with a pair of runs batted in for the Pirates, who pounded out a season-high 19 hits en route to topping the Yankees for the first time in regular season play. Adam LaRoche was also 3-for-5 with two RBI and Freddy Sanchez was 3-for-5 with an RBI and three runs scored.

"We swung the bats very well (and) kept the pressure on the whole game," Pirates manager John Russell said. "When you face a lineup like that, you like to score as many runs as you can. They're a threat at anytime. We kept adding on late, which is very important against a team like this."

Tom Gorzelanny (6-6), who came into the game with a woeful 6.59 earned run average, allowed three runs on six hits in six innings to pick up the win.

Bobby Abreu had a two-run homer for the Yankees, who have dropped three of their last four games. Rookie Justin Christian, who was called up before the game from Triple-A Scranton/Wilkes Barre, was 2-for-4 with a two-run double and Robinson Cano was 3-for-4 with an RBI.

Darrell Rasner (4-5) was awful on the hill for New York. The right-hander was touched for seven runs on 10 hits in five ineffective innings.

The Pirates jumped on top with a pair of runs in the first. Nate McLouth led off with a double to the gap in right-center, advanced to third when Rasner uncorked a wild pitch and scored on Sanchez's single to left.

Meanwhile, Sanchez advanced to second on the play when Christian bobbled his base hit and eventually crossed the plate on LaRoche's two-out run-scoring single.

Pittsburgh added another run in the third when Sanchez ripped a one-out single to left and Jason Bay laced an RBI double to deep center.

The Yankees finally scratched out a run against Gorzelanny in the fourth after Jorge Posada slapped a two-out double to left and Cano came through with a run-scoring single.

It could have been much worse, however. After the single by Cano, Gorzelanny loaded the bases by giving up a single to Christian, his first big league hit, and issuing a walk to Rasner. Melky Cabrera then crushed a Gorzelanny offering down the left field then went just foul, missing a grand slam by a few feet. Cabrera then grounded out weakly to end the inning.

"(Gorzelanny) was struggling with his control, (but) we couldn't have that one big inning," Derek Jeter said. "He made some pitches when he needed to get out of it. They literally were hitting from the first pitch of the game."

The Pirates followed by taking total control in the bottom of the fourth on Bautista's two-run homer. Doug Mientkiewicz, a former Yankee, led off with a single to right before Bautista crushed his ninth homer of the year over the wall in left to make it a 5-1 game.

Pittsburgh continued to pepper Rasner in the fifth. Doumit crushed a two-out, solo homer into the bleachers in right-center. LaRoche followed by lacing a triple off the top of the wall in dead center and then crossed the plate after Rasner unleashed his second wild pitch of the game.

The Yankees tried to chip away and managed two runs in the sixth. Jason Giambi was hit by a pitch and advanced to third on Cano's one-out double before Christian laced a two-out double to left making it a 7-3.

The Pirates rebounded and put things away off LaTroy Hawkins in the seventh. Bay grounded a double down the left field line, moved to third on a Doumit base hit and crossed the plate when LaRoche singled past a drawn-in infield. Mientkiewicz capped the frame with a sacrifice fly to right and Pittsburgh had a commanding 9-3 edge.

Pittsburgh kept pouring it on in the eighth. With runners at first and second and two down, Nyjer Morgan greeted Edwar Ramirez by lacing a two-run double to right. Doumit followed with another RBI two-bagger to extend the Pirates lead to 12-3.

Abreu's two-run homer in the ninth accounted for the final margin.