Boston, MA (Sports Network) - David Ortiz hit a three-run homer and scored twice to lead Boston over Milwaukee, 5-3, in the first installment of a doubleheader from Fenway Park.

Jacoby Ellsbury and J.D. Drew also drove in runs for the Red Sox, who snapped a four-game skid.

Daisuke Matsuzaka (7-0) went 6 2/3 innings for the win, allowing two unearned runs and seven hits, fanning six with a pair of walks.

"He got into a rhythm as the game progressed," said Sox manager Terry Francona of his starter. "He did a good job. He threw his off speed for strikes. He had the one long inning but other than that everything was 12, 13, 10, 11 pitches. He was around the plate."

He became the second Boston starter in as many seasons to win his first seven decisions, lowering his ERA to 2.15 in the process. Jonathan Papelbon recorded the final three outs in the contest for his 12th save.

Mike Cameron smacked a two-run home run and Ryan Braun added a solo homer for the Brewers, who have dropped three straight games.

Starter Jeff Suppan (2-3) took the loss for Milwaukee, charged with nine hits and four runs over six frames.

Game 2 is scheduled to begin at 8:35 p.m. (et), with Dave Bush on the hill for Milwaukee opposing veteran Boston knuckleballer Tim Wakefield.

The Sox put a two-out run on the board in their first at-bat. Ortiz walked, moved to second when Manny Ramirez was plunked, went to third on a Kevin Youkilis single and scored on a bases-loaded walk to Drew.

Ortiz made it 4-0 in the second with a three-run blast over the Green Monster, and Matsuzaka worked out of a bases-loaded jam in the fifth to keep the Brewers off the board.

"I was going in and it ran to the other side of the plate and in that situation, thats not where I want to throw it," Suppan said of the Ortiz homer.

A Youkilis error on Rickie Weeks' grounder to third put a runner on with two outs in the seventh, and Cameron cleared the Monster in left-center to bring the Brewers within 4-2.

Ellsbury added an RBI double in the eighth for an insurance run, which was key when Papelbon allowed Braun's two-out homer in the ninth. Prince Fielder then popped out to end the game.