(Sports Network) - A pair of American League West rivals get together tonight at Seattle's Safeco Field, where the division-leading LA Angels of Anaheim begin a six-game road trip with the first of three straight meetings with the last-place Mariners.

The Angels come in with a comfortable 3 1/2-game advantage on second-place Oakland in the West standings and have won 10 of their last 15 games following Sunday's 4-3 comeback victory over Toronto.

Anaheim trailed 3-2 heading into the bottom of the ninth inning, but drew even when Blue Jays closer hit Howie Kendrick with a pitch as the bases were loaded. Maicer Izturis followed with a single to right field to plate Casey Kotchman with the winning run.

Izturis finished 2-for-4 for the Angels, who took the final two tests of a three-game series with Toronto, while Sean Rodriguez socked a two-run homer in the win.

Jose Arrendondo (2-0) received the win after tossing 2 1/3 scoreless innings of relief. Angels starter Jon Garland worked the first five frames and gave up three runs while issuing four walks.

The disappointing Mariners own the AL's worst record at 21-36 and are already 12 1/2 games behind Anaheim in the standings. Seattle has gone 3-3 thus far on a nine-game homestand and just lost two of three matchups with Detroit over the weekend.

In Sunday's rubber match of a three-game series with the Tigers, Detroit erupted for four runs in the top of the ninth inning en route to a 7-5 victory.

J.J. Putz (2-3) entered for the Mariners with the contest tied at 3-3 in the ninth and was rocked for four runs on four hits while recording just two outs to suffer the loss.

Raul Ibanez cut Seattle's deficit in half with a two-run homer in the bottom of the ninth inning and finished 3-for-5 with three RBI. Adrian Beltre finished with two hits, including a solo home run, for the Mariners, who pounded out 15 hits as a team but stranded 12 baserunners.

Former Angel Jarrod Washburn will attempt to get the Mariners back on track in this evening's opener. The veteran lefty is coming off a solid six-inning effort at Yankee Stadium on May 25 in which he held New York to two runs and four hits despite not factoring in the decision.

Washburn rebounded from a horrid start at Detroit four days earlier, when he was rocked for nine runs and 12 hits over just 2 1/3 frames of a 9-4 loss.

The 33-year-old was drafted by the Angels organization in 1995 and spent his first eight major league seasons with Anaheim. Since joining the Mariners in 2006, Washburn is 4-3 with a 4.47 earned run average.

The Angels counter with Ervin Santana, who seeks to improve on an already- strong 7-2 record and 3.09 ERA in his 11 starts this season.

Santana tossed a complete-game gem in Tuesday's 3-2 triumph over Detroit, with the right-hander holding the Tigers to three hits and striking out seven without a walk.

The 25-year-old is 4-2 with a 4.93 ERA over eight previous starts against Seattle and beat the Mariners in Anaheim on April 19. Santana delivered eight outstanding innings in that game and yielded just one run on three hits while fanning eight.

However, Santana has allowed 15 runs and three homers in 13 2/3 innings during his three lifetime starts at Safeco Field.

These clubs have split six prior meetings this season, with Seattle winning two of three encounters with the Angels at home from April 11-13. The Angels took 13 of 19 contests from the Mariners last season and posted a 6-3 mark at Safeco in 2007.