(Sports Network) - The Boston Red Sox hope Daisuke Matsuzaka can put the brakes on their four-game losing streak this evening, as they welcome the Milwaukee Brewers back to Fenway Park for the first time in nearly 11 years.

Boston, which hasn't played the Brewers since taking two of three from them back in 2003, will be hosting Milwaukee for the first time since taking two of three from it on September 5-7, 1997, the Brewers' last season in the AL.

The Red Sox, though, come into this three-game interleague set following a 4-6 road trip, which included a 6-3 setback to the Baltimore Orioles on Wednesday at Camden Yards. Jason Varitek and Mike Lowell homered while Jacoby Ellsbury had three hits and scored a run for Boston, which failed to protect a three- run lead for the second consecutive game.

Sox reliever Craig Hansen (0-2) took the loss, charged with two runs while not recording an out. Starter Jon Lester was solid, giving up five hits and two runs over six frames.

Boston is also expected to have manager Terry Francona back in the dugout this evening. Francona missed the Orioles series to attend the funeral of his mother-in-law.

Matsuzaka, meanwhile, has been brilliant for the BoSox this season, going 6-0 with a splendid 2.45 earned run average. He won his second game in as many starts on Saturday against Minnesota, as he held the Twins to two runs and six hits in seven innings.

If there has been one knock on Matsuzaka this season it is his walks allowed. He has issued 30 free passes this season, the second highest amount in the league behind Cleveland righty Fausto Carmona's 35.

Milwaukee will counter with veteran Jeff Suppan, who is 2-2 with a 4.63 ERA. Suppan picked up the win on Sunday against St. Louis, as he allowed a run and six hits in seven innings.

Suppan is 3-3 lifetime versus the Sox with a 4.78 ERA in eight starts.

The Brewers enter this series after dropping the final two games of their three-game series with the Los Angeles Dodgers, including a 7-2 setback in Thursday's finale at Miller Park.

On the day he signed an eight-year, $45 million contract, Ryan Braun homered for the Brewers, whose slide comes after a three-game win streak.

Ben Sheets (4-1) threw six shutout innings before imploding in the seventh and was charged with six runs on nine hits over 6 1/3 frames.

Boston was 12-6 last season in interleague play, while the Brewers went 8-7 versus the Junior Circuit. The Red Sox are also 16-3 in their last 19 interleague games at Fenway Park.