(Sports Network) - Matt Garza tries to help the Tampa Bay Rays go 2-0 for the first time since they won their first three tests of the 2002 campaign when the team continues a season-opening three-game series against the Baltimore Orioles tonight at Camden Yards.

Tampa Bay, which has opened a year with two straight wins just twice in team history, ended Baltimore's string of seven straight home-opening wins on Monday, as B.J. Upton's two-RBI single keyed a three-run third inning which lifted the Rays to a 6-2 win.

Eric Hinske homered for the Rays, who won their first Opening Day road game since a 7-0 decision over the Twins on April 3, 2000. Carl Crawford, Dioner Navarro and Jason Bartlett also drove in a run apiece.

Tampa starter James Shields allowed five hits and two runs over seven innings, fanning two but walking three.

Kevin Millar drove in the only runs for the Orioles, who had not lost a home game to open the season since a 2000 setback to Cleveland. Brian Roberts finished 2-for-2 with a run scored in the loss.

Baltimore starter Jeremy Guthrie was charged with nine hits and six runs -- five earned -- over 5 1/3 frames.

Garza, acquired from Minnesota this past offseason in the Delmon Young deal, appeared in 16 games (15 starts) for the Twins last year and went 5-7 with a 3.69 earned run average.

He has been sensational against the O's in his young career, though. Garza has won all three of his starts against Baltimore while pitching to a 2.16 ERA.

The Orioles will counter with right-hander Daniel Cabrera, who was a huge disappointment a season ago. After leading the AL with 104 walks in 2006, Cabrera once again topped the league in that category last season (108) and also dropped a league-high 18 games. He also allowed as many home runs (25) last year as he did in the two previous seasons combined, although Cabrera did set a career-high with 34 starts.

Tampa, though, was one of the few teams that Cabrera was able to beat last season, as three of his nine wins came at the Rays' expense. For his career Cabrera is a perfect 6-0 with a 3.04 ERA versus the Rays.

Baltimore won 11 of its 18 matchups with the Rays last season and is 36-20 against them since the start of the 2005 campaign. Tampa, though, has won its last four at Camden Yards after losing nine in a row there.